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Nuclear actin is exported from the nucleus via the Exportin-6 (XPO6)/RAN GTPase complex. We recently identified that RASSF1A and the hippo pathway kinase Mammalian STE20-like protein kinase 2 (MST2) play a pivotal role in nucleocytoplasmic shuttling of actin by regulating the association of XPO6 with RAN GTPase. Importantly, loss of Ras association domain family 1A (RASSF1A) and hippo signaling in cancer cells highlights a key mechanism by which nuclear actin promotes tumorigenesis.

Original publication

DOI

10.1080/23723556.2019.1638728

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

2019

Volume

6

Keywords

Exportin-6, MRTF-A, Nuclear actin, RASSF1A, cancer