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This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.

Original publication

DOI

10.1016/j.radonc.2017.05.003

Type

Journal article

Journal

Radiother Oncol

Publication Date

09/2017

Volume

124

Pages

365 - 369

Keywords

Cognition’s preservation, Flash-RT, Whole brain irradiation, Animals, Brain, Cranial Irradiation, Dose-Response Relationship, Radiation, Female, Hippocampus, Humans, Memory, Mice, Mice, Inbred C57BL, Neurogenesis, Radiation Injuries, Experimental