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© 2017 The Authors. Published by Elsevier Ireland Ltd on behalf of European Society of Radiotherapy & Oncology. We present a clinical distance measure for Pareto front evaluation studies in radiotherapy, which we show strongly correlates (r=0.74 and 0.90) with clinical plan quality evaluation. For five prostate cases, sub-optimal treatment plans located at a clinical distance value of > 0.32 (0.28-0.35) from fronts of Pareto optimal plans, were assessed to be of lower plan quality by our (12) observers (p < .05). In conclusion, the clinical distance measure can be used to determine if the difference between a front and a given plan (or between different fronts) corresponds to a clinically significant plan quality difference.

Original publication




Journal article


Physics and Imaging in Radiation Oncology

Publication Date





53 - 56