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Antisense oligonucleotides are now entering the clinic for hard-to-treat diseases. New chemical modifications are urgently required to enhance their drug-like properties. We combine amide coupling with standard oligonucleotide synthesis to assemble backbone chimera gapmers that trigger an efficient RNase H response while improving serum life time and cellular uptake.

Original publication

DOI

10.1039/d0cc00444h

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

15/04/2020