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Monoclonal antibodies reacting with the herpes simplex virus (HSV)-encoded major DNA-binding protein defined an intracellular filamentous network. This network was associated predominantly with the infected cell nucleus and occurred in cells infected with HSV type 2. It did not co-distribute with microfilaments, microtubules or intermediate filaments, and DNA synthesis was required for its formation. We suggest explanations for the occurrence and function of this novel filamentous network structure.

Original publication

DOI

10.1099/0022-1317-67-7-1315

Type

Journal article

Journal

The Journal of general virology

Publication Date

01/01/1986

Volume

67 ( Pt 7)

Pages

1315 - 1325