Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.
Kho P-F., Amant F., Annibali D., Ashton K., Attia J., Auer PL., Beckmann MW., Black A., Brinton L., Buchanan DD., Chanock SJ., Chen C., Chen MM., Cheng THT., Cook LS., Crous-Bous M., Czene K., De Vivo I., Dennis J., Dörk T., Dowdy SC., Dunning AM., Dürst M., Easton DF., Ekici AB., Fasching PA., Fridley BL., Friedenreich CM., García-Closas M., Gaudet MM., Giles GG., Goode EL., Gorman M., Haiman CA., Hall P., Hankinson SE., Hein A., Hillemanns P., Hodgson S., Hoivik EA., Holliday EG., Hunter DJ., Jones A., Kraft P., Krakstad C., Lambrechts D., Le Marchand L., Liang X., Lindblom A., Lissowska J., Long J., Lu L., Magliocco AM., Martin L., McEvoy M., Milne RL., Mints M., Nassir R., Otton G., Palles C., Pooler L., Proietto T., Rebbeck TR., Renner SP., Risch HA., Rübner M., Runnebaum I., Sacerdote C., Sarto GE., Schumacher F., Scott RJ., Setiawan VW., Shah M., Sheng X., Shu X-O., Southey MC., Tham E., Tomlinson I., Trovik J., Turman C., Tyrer JP., Van Den Berg D., Wang Z., Wentzensen N., Xia L., Xiang Y-B., Yang HP., Yu H., Zheng W., Webb PM., Thompson DJ., Spurdle AB., Glubb DM., O'Mara TA.
Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P