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The protease SPRTN emerged as the essential enzyme for DNA-protein crosslink proteolysis repair. Biochemical and cell biological work indicated that SPRTN is a nonspecific protease. Recent and independent studies from Lou, Stingele, and Ramadan reveal that SPRTN activity is modulated via three layers of regulation that make it selective for DNA-protein crosslinks.

Original publication




Journal article


Trends Biochem Sci

Publication Date



DNA–protein crosslinks, SPRTN protease, cancer, genomic instability