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The mammalian homologue of the Drosophila axonal guidance receptor roundabout is expressed in a wide range of tissues. Here we show that alternative splicing of the Dutt1/Robo1 gene results in two mRNA transcripts with different signal peptides, which are differentially expressed throughout mouse embryogenesis. Since mice with a targeted deletion in the Dutt1/Robo1 gene have abnormal lung pathology, immunohistochemistry was used to identify the cellular expression pattern of Dutt1/Robo1 during lung development. Dutt1/Robo1 expression was widespread and diffuse in the lung at embryonic day 17.5 but became increasingly localised to the bronchial epithelium in newborn and adult mice.

Original publication




Journal article



Publication Date





12 - 16


Alternative Splicing, Amino Acid Sequence, Animals, Bronchi, Epithelium, Gene Deletion, Gene Expression Regulation, Developmental, Immunohistochemistry, Lung, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Protein Isoforms, Protein Sorting Signals, RNA, Messenger, Receptors, Immunologic, Tissue Distribution