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The mammalian homologue of the Drosophila axonal guidance receptor roundabout is expressed in a wide range of tissues. Here we show that alternative splicing of the Dutt1/Robo1 gene results in two mRNA transcripts with different signal peptides, which are differentially expressed throughout mouse embryogenesis. Since mice with a targeted deletion in the Dutt1/Robo1 gene have abnormal lung pathology, immunohistochemistry was used to identify the cellular expression pattern of Dutt1/Robo1 during lung development. Dutt1/Robo1 expression was widespread and diffuse in the lung at embryonic day 17.5 but became increasingly localised to the bronchial epithelium in newborn and adult mice. © 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

Original publication

DOI

10.1016/S0014-5793(02)02904-6

Type

Journal article

Journal

FEBS Letters

Publication Date

01/01/2002

Volume

523

Pages

12 - 16