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[(18)F]-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) is becoming accepted as a diagnostic tool for cancer, but the potential uses of PET in oncology extend beyond the imaging of glucose metabolism. The development of a PET proliferation probe would be a useful pharmacodynamic tool. [(11)C]-thymidine PET has been assessed in man as a specific measure of tumor proliferation. Uptake of [(11)C]-thymidine is related to DNA synthesis and, in human tumors, correlates with proliferation. When compared with (18)F-FDG, it has been shown to be a more sensitive discriminator of early clinical tumor response. 2-[(11)C]-thymidine PET scanning of patients enrolled in early phase clinical trials is feasible and should support future drug development. Although recent research is moving away from the validation of thymidine towards thymidine analogues radiolabeled with (18)F, the better specificity of thymidine for DNA should be the rationale for its continued development and application as a PET probe. This review describes the historical development, application and current research status of [(11)C]-thymidine PET, and aims to highlight the need for its continuing development as a marker of tumor proliferation.

Original publication

DOI

10.1016/j.bbcan.2004.09.007

Type

Journal article

Journal

Biochim Biophys Acta

Publication Date

17/12/2004

Volume

1705

Pages

91 - 102

Keywords

Carbon Radioisotopes, Cell Proliferation, Clinical Trials as Topic, DNA Probes, Fluorodeoxyglucose F18, Humans, Neoplasms, Positron-Emission Tomography, Reproducibility of Results, Thymidine