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Intense investigation into the molecular basis of angiogenesis is rapidly revealing novel signaling pathways involved in the generation of new vasculature. These range from elucidation of the mechanism by which hypoxia initiates expression of a proangiogenic gene repertoire via the hypoxia-inducible transcription factors (HIFs) to molecular pathways involved in extra- and intracellular signaling during new vessel formation. Extracellular pathways include those of the Notch/delta, ephrin/Eph receptor and roundabout/slit families, and intracellular pathway members of the hedgehog and sprouty families. The involvement of these pathways in angiogenesis is discussed, together with some comments on recently identified targets in the vasculature that present new therapeutic opportunities.

Original publication




Journal article


Annu Rev Pharmacol Toxicol

Publication Date





219 - 238


Animals, Blood Vessels, Cancer Vaccines, Cell Hypoxia, Humans, Ligands, Neoplasms, Neovascularization, Pathologic, Neovascularization, Physiologic, Receptors, Vascular Endothelial Growth Factor, Signal Transduction, Vascular Endothelial Growth Factor A