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Cytosine-5-methylation stabilises DNA duplexes and is associated with transcriptional repression; 5-methylcytosine undergoes hydroxylation to 5-hydroxymethylcytosine, a modification of unknown biological function. Spectroscopic and calorimetric analyses show that 5-hydroxymethylcytosine introduction reverses the stabilising effect of 5-methylcytosine, suggesting that in some contexts, 5-methylcytosine hydroxylation may, along with other factors, contribute to the alleviation of transcriptional repression.

Original publication

DOI

10.1039/c0cc05671e

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

14/05/2011

Volume

47

Pages

5325 - 5327

Keywords

5-Methylcytosine, Base Sequence, Cytosine, Cytosine Nucleotides, DNA, DNA Methylation, Dinucleoside Phosphates, Humans, Hydroxylation, Methylation, Molecular Sequence Data, Molecular Structure, Polymerase Chain Reaction