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Base excision repair (BER) is the major mechanism for processing of mutagenic and genotoxic DNA base lesions caused by cellular environmental or exogenous mutagens. In vitro base excision repair assays have been used in studies aimed at understanding the nature of various human diseases, aging and mechanisms of genome recovery after mutagenic stress. This review describes the key base excision repair assays and addresses their advantages and limitations.

Type

Journal article

Journal

Toxicology

Publication Date

15/11/2003

Volume

193

Pages

35 - 41

Keywords

Animals, Base Sequence, Biological Assay, DNA Repair, DNA, Circular, Humans, In Vitro Techniques, Molecular Sequence Data