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BER (base excision repair) is a major pathway for the removal of simple lesions in DNA including base damage and base loss (abasic site). We have developed an assay, using formaldehyde cross-linking during repair in human cell extracts, to observe BER proteins involved in the repair of damaged DNA. This approach allows visualization of repair proteins on damaged DNA during BER in human cell extracts and provides a detailed view of the molecular events leading to repair.

Original publication

DOI

10.1042/BST0320962

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

12/2004

Volume

32

Pages

962 - 963

Keywords

DNA Damage, DNA Repair, DNA, Neoplasm, Formaldehyde, HeLa Cells, Humans