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Ultrasoft X-rays have been shown to be very efficient in inducing chromosomal aberrations in mammalian cells. The present study was aimed to evaluate the modifying effects of DMSO (a potent scavenger of free radicals) on the frequencies of chromosome aberrations induced by soft X-rays. Confluent held G1 Chinese hamster cells (V79) were irradiated with Carbon K ultrasoft X-rays in the presence and absence of 1M DMSO and frequencies of chromosome aberrations in the first division cells were determined. DMSO reduced the frequencies of exchange types of aberrations (dicentrics and centric rings) by a factor of 2.1-3.5. The results indicate that free radicals induced by ultrasoft X-rays contribute to a great extent to the induction of chromosome aberrations. The possible implications of these results in interpreting the mechanisms involved in the high efficiency of ultrasoft X-rays in the induction of chromosome aberrations are discussed.

Original publication

DOI

10.1016/j.mrfmmm.2010.06.008

Type

Journal article

Journal

Mutat Res

Publication Date

10/09/2010

Volume

691

Pages

23 - 26

Keywords

Animals, Carbon, Cell Line, Chromosome Aberrations, Cricetinae, Cricetulus, Dimethyl Sulfoxide, X-Rays