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<p>Banoxantrone (BN) induces modification of tumor hypoxia in Calu6 xenografts. <b>A,</b> TMR of [<sup>18</sup>F] FAZA uptake is increased from baseline at day 1 and 3 in control tumors (Cn; white bars) but was reduced in drug-treated tumors. <b>B,</b> Example, [<sup>18</sup>F] FAZA PET images with greatest hypoxia represented by orange and red. <b>C,</b> Tumor MRI hypoxic fraction showed similar relative reduction at day 1 and 3, relative to control tumors. <b>D,</b> Example segmented MRI images showing hypoxic (blue), normoxic (yellow), and necrotic (gray) tumor. <b>E,</b> Lower percentage of pimonidazole staining was detected in drug-treated tumors at day 3, compared to controls. <b>F,</b> Example pimonidazole adduct formation images (×40 magnification).</p>

Original publication

DOI

10.1158/2767-9764.27144155

Type

Other

Publication Date

01/10/2024