Figure 5 from Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett’s Esophagus Using EMI-137 Fluorescence Imaging
Huang Y-J., Rieder J., Tan KV., Tenditnaya A., Vojnovic B., Gorpas D., Quante M., Vallis KA.
<p><i>Ex vivo</i> fluorescence imaging of L2-IL1β mice: <b>A,</b> Representative white light and fluorescence images of the excised stomach taken from L2-IL1β mice. The white dotted line shows the SCJ, which is within the stomach in mice. A protruding, irregular lesion is visible at the EGJ and SCJ in the stomach taken from a high-score group mouse, with the corresponding fluorescence image below. <b>B,</b> Upregulation of c-MET in dysplastic lesions from the low-, intermediate-, and high-score groups. <b>C,</b> Correlation between dysplasia score and level of c-MET expression. <b>D,</b> Box-whisker plot of ROI analysis, which shows increasing fluorescence from low- to intermediate- to high-score lesions. <b>E,</b> Quantification of TBR in <i>ex vivo</i> IVIS fluorescence imaging. Range of box-whisker plots indicate minimum to maximum. *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001; ****, <i>P</i> < 0.0001. Eso, esophagus; H&E, hematoxylin and eosin; Max, maximum; Min, minimum; ns, not significant; S<sub>bkg,</sub> signal intensities of the background; SJC, squamocolumnar junction; S<sub>lesion,</sub> signal intensities of the lesion.</p>