Figure 5 from Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett’s Esophagus Using EMI-137 Fluorescence Imaging
Huang Y-J., Rieder J., Tan KV., Tenditnaya A., Vojnovic B., Gorpas D., Quante M., Vallis KA.
Ex vivo fluorescence imaging of L2-IL1β mice: A, Representative white light and fluorescence images of the excised stomach taken from L2-IL1β mice. The white dotted line shows the SCJ, which is within the stomach in mice. A protruding, irregular lesion is visible at the EGJ and SCJ in the stomach taken from a high-score group mouse, with the corresponding fluorescence image below. B, Upregulation of c-MET in dysplastic lesions from the low-, intermediate-, and high-score groups. C, Correlation between dysplasia score and level of c-MET expression. D, Box-whisker plot of ROI analysis, which shows increasing fluorescence from low- to intermediate- to high-score lesions. E, Quantification of TBR in ex vivo IVIS fluorescence imaging. Range of box-whisker plots indicate minimum to maximum. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Eso, esophagus; H&E, hematoxylin and eosin; Max, maximum; Min, minimum; ns, not significant; Sbkg, signal intensities of the background; SJC, squamocolumnar junction; Slesion, signal intensities of the lesion.