Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

E2F is a family of transcription factors implicated in cell cycle control. To understand the role of E2F in controlling cell cycle progression, it is necessary to clarify the breadth of the E2F family. To date, seven E2F subunits have been identified. We report here the characterization of a new E2F subunit, E2F-8, which resembles the organization of E2F-7 in the presence of two separate DNA-binding domains, the integrity of which is required for E2F-8 to bind to DNA. Furthermore, like E2F-7, we find that E2F-8 can repress transcription and delay cell cycle progression. The similarities between E2F-7 and E2F-8 define a new subgroup of the E2F family, and further imply that E2F-7 and E2F-8 may act through overlapping mechanisms in mediating cell cycle control.

Original publication

DOI

10.1038/sj.onc.1208703

Type

Journal article

Journal

Oncogene

Publication Date

21/07/2005

Volume

24

Pages

5000 - 5004

Keywords

Amino Acid Sequence, Animals, Cell Line, Tumor, DNA-Binding Proteins, E2F7 Transcription Factor, Humans, Mice, Molecular Sequence Data, Repressor Proteins, Transcription Factors