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The Stress-responsive activator of p300 (Strap) is a transcription cofactor that has an important role in the control of DNA damage response through its ability to regulate p53 activity. Here, we report that Strap is inducible by heat shock and stimulates the transcription of heat-shock genes. A chromatin-associated complex involving heat-shock factor 1 (HSF1), Strap and the p300 coactivator assembles on the heat-shock protein 70 (hsp70) promoter, and Strap augments HSF1 binding and chromatin acetylation in Hsp genes, most probably through the p300 histone acetyltransferase. Cells depleted of Strap do not survive under heat-shock conditions. These results indicate that Strap is an essential cofactor that acts at the level of chromatin control to regulate heat-shock-responsive transcription.

Original publication

DOI

10.1038/embor.2008.70

Type

Journal article

Journal

EMBO Rep

Publication Date

07/2008

Volume

9

Pages

662 - 669

Keywords

Acetylation, Carrier Proteins, Cell Line, Tumor, Cell Survival, Chromatin, DNA-Binding Proteins, Gene Expression Regulation, HSP70 Heat-Shock Proteins, Heat Shock Transcription Factors, Heat-Shock Response, Humans, Promoter Regions, Genetic, Protein Binding, Transcription Factors, p300-CBP Transcription Factors