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Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear transcription factors that regulate the cellular response to hypoxia and are important for solid tumor growth and survival. Overexpression of HIF-1alpha and HIF-2alpha was demonstrated in three HNSCC cell lines under hypoxia and tumor tissue versus normal tissue (n = 20, HIF-1alpha, P = 0.023; HIF-2alpha, P = 0.013). On immunostaining, HIF-1alpha and HIF-2alpha expression were localized to tumor nuclei; HIF-2alpha expression was also seen in tumor-associated macrophages. Expression of HIF-1alpha in surgically treated patients with HNSCC (n = 79) was associated with improved disease-free survival (P = 0.016) and overall survival (P = 0.027).


Journal article


Cancer Res

Publication Date





2493 - 2497


Adolescent, Adult, Aged, Aged, 80 and over, Basic Helix-Loop-Helix Transcription Factors, Carcinoma, Squamous Cell, Disease-Free Survival, HeLa Cells, Head and Neck Neoplasms, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Immunohistochemistry, L-Lactate Dehydrogenase, Middle Aged, Necrosis, Survival Rate, Trans-Activators, Transcription Factors, Treatment Outcome