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The DNA integrity checkpoint and stress kinase (SAPK/JNK and p38) pathways function to modulate cell-cycle, apoptotic and transcriptional responses to stress. Although initially considered to function independently, recent advances indicate a number of links between the stress-response and checkpoint pathways. Here, we consider the relationship between the stress-response and checkpoint pathways and how they interact to modulate cell-cycle control.

Type

Journal article

Journal

Trends Cell Biol

Publication Date

10/2001

Volume

11

Pages

426 - 433

Keywords

Animals, Apoptosis, Cell Cycle, Checkpoint Kinase 1, Checkpoint Kinase 2, DNA Damage, DNA Replication, MAP Kinase Signaling System, Models, Biological, Oxidative Stress, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, Signal Transduction, Transcription, Genetic, Yeasts