Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The DNA integrity checkpoint and stress kinase (SAPK/JNK and p38) pathways function to modulate cell-cycle, apoptotic and transcriptional responses to stress. Although initially considered to function independently, recent advances indicate a number of links between the stress-response and checkpoint pathways. Here, we consider the relationship between the stress-response and checkpoint pathways and how they interact to modulate cell-cycle control.


Journal article


Trends Cell Biol

Publication Date





426 - 433


Animals, Apoptosis, Cell Cycle, Checkpoint Kinase 1, Checkpoint Kinase 2, DNA Damage, DNA Replication, MAP Kinase Signaling System, Models, Biological, Oxidative Stress, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, Signal Transduction, Transcription, Genetic, Yeasts