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Angiogenesis is the process by which tumours induce a blood supply, crucial for growth and metastasis. Evidence for its role in bladder carcinogenesis, its usefulness as a marker of patient prognosis, and potential anti-angiogenic therapies for future development are discussed in this chapter.


Journal article


Surg Oncol

Publication Date





85 - 100


Angiogenesis Inducing Agents, Angiogenesis Inhibitors, Animals, Cyclohexanes, DNA-Binding Proteins, Drug Combinations, Endothelial Growth Factors, Humans, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Lymphokines, Mice, Mice, Nude, Neovascularization, Pathologic, Nuclear Proteins, O-(Chloroacetylcarbamoyl)fumagillol, Piperidines, Quinazolines, Quinazolinones, Sesquiterpenes, Thymidine Phosphorylase, Transcription Factors, Urinary Bladder Neoplasms, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors