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We investigated the expression of MUC1 protein and its relationship to the microvessel density and the expression of thymidine phosphorylase, vascular endothelial growth factor (VEGF), VEGF-receptor KDR, basic fibroblast growth factor (bFGF), and bFGF-receptor (FGFR-2) in non-small cell lung cancer. Although MUC1 expression was found equally in poorly and highly vascularized tumors, a significant coexpression with multiple angiogenic factors and their receptors was noted (P = 0.0002, 0.03, 0.19, 0.10, and 0.01 for thymidine phosphorylase, VEGF, KDR, bFGF, and FGFR-2, respectively). In multiple regression analysis, both angiogenesis and MUC1 expression were independent prognostic variables. The present study suggests the existence of an early genetic event leading to the activation of both migration and angiogenesis pathways in non-small cell lung cancer.

Type

Journal article

Journal

Clin Cancer Res

Publication Date

05/2000

Volume

6

Pages

1917 - 1921

Keywords

Adult, Aged, Angiogenesis Inducing Agents, Carcinoma, Non-Small-Cell Lung, Endothelial Growth Factors, Female, Fibroblast Growth Factor 2, Humans, Immunohistochemistry, Lung Neoplasms, Lymphokines, Male, Middle Aged, Mucin-1, Neoplasm Metastasis, Neoplasm Staging, Neovascularization, Pathologic, Receptor Protein-Tyrosine Kinases, Receptor, Fibroblast Growth Factor, Type 2, Receptors, Fibroblast Growth Factor, Receptors, Growth Factor, Receptors, Vascular Endothelial Growth Factor, Thymidine Phosphorylase, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors