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The p53 tumour suppressor protein functions as a guardian against genotoxic stress. This function is mediated in part by the transcriptional activation of genes involved in cell-cycle arrest, apoptosis, DNA repair and autophagy. The activity of p53 is regulated by a complex array of post-translational modifications, which function as a code to determine cellular responses to a given stress. In this chapter we highlight recent advances in our understanding of this code, with particular reference to lysine methylation, and discuss implications for future research.

Original publication

DOI

10.1042/bse0520079

Type

Journal article

Journal

Essays Biochem

Publication Date

2012

Volume

52

Pages

79 - 92

Keywords

Animals, Humans, Lysine, Methylation, Models, Biological, Tumor Suppressor Protein p53