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Cell cycle transitions are driven by the periodic oscillations of cyclins, which bind and activate cyclin-dependent kinases (CDKs) to phosphorylate target substrates. Cyclin F uses a substrate recruitment strategy similar to that of the other cyclins, but its associated catalytic activity is substantially different. Indeed, cyclin F is the founding member of the F-box family of proteins, which are the substrate recognition subunits of Skp1-Cul1-F-box protein (SCF) ubiquitin ligase complexes. Here, we discuss cyclin F function and recently identified substrates of SCF(cyclin)(F) involved in deoxyribonucleotide triphosphate (dNTP) production, centrosome duplication, and spindle formation. We highlight the relevance of cyclin F in controlling genome stability through ubiquitin-mediated proteolysis and the implications for cancer development.

Original publication

DOI

10.1016/j.tcb.2012.10.011

Type

Journal article

Journal

Trends Cell Biol

Publication Date

03/2013

Volume

23

Pages

135 - 140

Keywords

Animals, Cell Cycle, Cyclins, Gene Expression Regulation, Genome, Human, Genomic Instability, Humans, Protein Subunits, Proteolysis, Ribonucleoside Diphosphate Reductase, SKP Cullin F-Box Protein Ligases, Signal Transduction, Ubiquitin