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The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

Original publication

DOI

10.1039/c2cc35407a

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

07/10/2012

Volume

48

Pages

9592 - 9594

Keywords

Base Sequence, Cross-Linking Reagents, DNA, Molecular Sequence Data, Nanostructures