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Two new dibenzocyclooctyne-thymidine monomers were incorporated into oligonucleotides and crosslinked to azide-labelled complementary strands across the DNA grooves. Equivalent reactions were successful using a (bicyclo[6.1.0]nonyne) alkyne. Oligonucleotides containing internal cyclooctyne and amino groups were simultaneously reacted with azides and NHS esters of different fluorescent dyes to produce functional genetic probes.

Original publication

DOI

10.1039/c2cc35084j

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

25/11/2012

Volume

48

Pages

11184 - 11186

Keywords

Alkynes, Azides, Click Chemistry, Copper, Fluorescent Dyes, Nucleic Acid Conformation, Oligonucleotides, Thymidine