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A DNA strand containing a triazole phosphodiester mimic is an efficient template for in vitro transcription. This is the first demonstration of transcription through a heavily modified DNA backbone linkage and it suggests that click-ligated DNA could be useful for the direct synthesis of biologically active RNA and proteins.

Original publication

DOI

10.1039/c1cc14316f

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

28/11/2011

Volume

47

Pages

12057 - 12058

Keywords

Click Chemistry, DNA, DNA-Directed RNA Polymerases, RNA, Transcription, Genetic, Triazoles, Viral Proteins