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The advent of click chemistry has led to an influx of new ideas in the nucleic acids field. The copper catalysed alkyne-azide cycloaddition (CuAAC) reaction is the method of choice for DNA click chemistry due to its remarkable efficiency. It has been used to label oligonucleotides with fluorescent dyes, sugars, peptides and other reporter groups, to cyclise DNA, to synthesise DNA catenanes, to join oligonucleotides to PNA, and to produce analogues of DNA with modified nucleobases and backbones. In this critical review we describe some of the pioneering work that has been carried out in this area (78 references).

Original publication

DOI

10.1039/b901971p

Type

Journal article

Journal

Chem Soc Rev

Publication Date

04/2010

Volume

39

Pages

1388 - 1405

Keywords

Alkynes, Azides, Catalysis, Copper, Cyclization, DNA, Oligonucleotides, Peptide Nucleic Acids