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Highly selective base-pair recognition makes DNA a suitable building block for orderly self-assembled structures. For some applications in nanotechnology DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes we have synthesised a thymidine monomer modified with a cholesterol moiety. Solution studies show that the melting temperature (Tm) of the duplex, with adjacent cholesterols on each strand, is much higher than that of the unmodified duplex.

Original publication

DOI

10.1080/15257770701501534

Type

Journal article

Journal

Nucleosides Nucleotides Nucleic Acids

Publication Date

2007

Volume

26

Pages

785 - 794

Keywords

Cholesterol, Fluorescence, Hydrogen-Ion Concentration, Nucleic Acid Denaturation, Oligonucleotides, Organophosphorus Compounds, Thymidine