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Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible.

Original publication

DOI

10.1080/15257770701533958

Type

Journal article

Journal

Nucleosides Nucleotides Nucleic Acids

Publication Date

2007

Volume

26

Pages

1363 - 1367

Keywords

Base Pairing, Cytosine, DNA, Guanine, Hydrogen Bonding, Nucleosides, Pyrimidinones, Pyrroles