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The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.

Original publication

DOI

10.1080/15257770701506491

Type

Journal article

Journal

Nucleosides Nucleotides Nucleic Acids

Publication Date

2007

Volume

26

Pages

921 - 925

Keywords

Anthraquinones, Base Sequence, Drug Design, Drug Stability, Fluorescence, Molecular Structure, Nucleic Acid Conformation, Oligodeoxyribonucleotides