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Synthetic chemistry has been central to the design of modern methods of genetic analysis. In this article, we discuss the underlying chemistry and biophysical principles that have been used in the development of robust methods for the analysis of DNA in the diagnostic laboratory.

Original publication

DOI

10.1039/b509522k

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

28/11/2005

Pages

5487 - 5502

Keywords

DNA, DNA Probes, Fluorescence, Molecular Structure, Polymerase Chain Reaction