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Synthetic chemistry has been central to the design of modern methods of genetic analysis. In this article, we discuss the underlying chemistry and biophysical principles that have been used in the development of robust methods for the analysis of DNA in the diagnostic laboratory.

Original publication




Journal article


Chem Commun (Camb)

Publication Date



5487 - 5502


DNA, DNA Probes, Fluorescence, Molecular Structure, Polymerase Chain Reaction