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Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.

Original publication

DOI

10.1039/b502325d

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

28/05/2005

Pages

2555 - 2557

Keywords

Base Pairing, Cytosine, DNA, Guanine, Hydrogen Bonding, Nucleic Acid Conformation, Nucleosides, Oligonucleotides, Pyrimidinones, Thymine