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A novel photocleavable universal support for the automated solid phase synthesis of oligonucleotides is described. The linker between the growing oligonucleotide chain and CPG support contains a nucleophilic amine protected with a photocleavable group. On exposure to UV light, this group is detached and the free amine affords cleavage of the oligonucleotide from the support. The use of long wavelength UV light avoids damage to the DNA.

Original publication

DOI

10.1081/NCN-120022996

Type

Journal article

Journal

Nucleosides Nucleotides Nucleic Acids

Publication Date

05/2003

Volume

22

Pages

1403 - 1406

Keywords

Base Sequence, DNA Damage, Indicators and Reagents, Molecular Structure, Oligodeoxyribonucleotides, Ultraviolet Rays