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The synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-nucleosidic analogues of natural nucleosides. © 2002 Elsevier Science Ltd. All rights reserved.

Original publication

DOI

10.1016/S0040-4039(02)00481-1

Type

Journal article

Journal

Tetrahedron Letters

Publication Date

22/04/2002

Volume

43

Pages

3121 - 3123