[<sup>1</sup>h, <sup>15</sup>n] NMR studies of the platination of phosphorothioate nucleotides - Monofunctional sulfur adducts versus macrochelation
Kratochwil NA., Parkinson JA., Sacht C., Del Socorro Murdoch P., Brown T., Sadler PJ.
cis-[PtI2(15NH3)2] reacts rapidly with guanosine-5′-O-(2-thiodiphosphate) (GDP-β-S) to form a macrochelate in which Pt bridges the phosphorothioate S and guanine N7 atoms. Phosphorothioate(α-S)-containing self-complementary decamer oligonucleotides give rise to relatively long lived S-bound monofunctional adducts, the fate of which is sequence dependent.