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cis-[PtI2(15NH3)2] reacts rapidly with guanosine-5′-O-(2-thiodiphosphate) (GDP-β-S) to form a macrochelate in which Pt bridges the phosphorothioate S and guanine N7 atoms. Phosphorothioate(α-S)-containing self-complementary decamer oligonucleotides give rise to relatively long lived S-bound monofunctional adducts, the fate of which is sequence dependent.

Original publication

DOI

10.1002/1099-0682(200111)2001:11<2743::AID-EJIC2743>3.0.CO;2-Z

Type

Journal article

Journal

European Journal of Inorganic Chemistry

Publication Date

01/01/2001

Pages

2743 - 2746