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The efficient incorporation of reporter groups into oligonucleotides at specific sites has been facilitated by the synthesis of a novel modified thymidine monomer with an FMOC-protected hydroxyl group on a linker. The primary hydroxyl group can be deprotected during or after solid-phase oligonucleotide synthesis and reacted with any reporter phosphoramidite. © 2001 Elsevier Science Ltd.

Original publication

DOI

10.1016/S0040-4039(01)00224-6

Type

Journal article

Journal

Tetrahedron Letters

Publication Date

26/03/2001

Volume

42

Pages

2587 - 2591