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A novel thymidine analogue containing both 5-aminopropargyl and 2'-aminoethoxy modifications has been synthesised and incorporated into a triplex-forming oligonucleotide; the combination of the two amino groups on the same nucleoside greatly enhances triplex stability.

Original publication

DOI

10.1039/b006268p

Type

Journal article

Journal

Chemical Communications

Publication Date

07/12/2000

Pages

2315 - 2316