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Compounds have been synthesized which allow the attachment of Vitamin E to the 5′-, and 3′-ends of oligonucleotides, and the attachment of a Vitamin E moiety on an octamethylene spacer to the 5′-end, all during solid-phase synthesis. The effects on cellular uptake, distribution, and antiviral activity of the attachment of the extremely lipophilic Vitamin E moiety to phosphorothioate 'antisense' oligonucleotides are now being investigated. © 1992.

Original publication

DOI

10.1016/S0040-4039(00)79068-X

Type

Journal article

Journal

Tetrahedron Letters

Publication Date

05/05/1992

Volume

33

Pages

2729 - 2732