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By the H-phosphonate approach on a solid support we have synthesised a 28-mer homopolymer of 2'-deoxycytidine (SdC28), a 28-mer phosphorothioate oligodeoxynucleotide (Srev) complementary to the HIV-1 regulatory gene and a number of its base modified derivatives. Anti HIV-1 activity of S-dC28 and Srev in chronically infected T-cells was studied. Melting temperatures of rev-comp rev and Srev-comp rev were also measured. © 1991, Taylor & Francis Group, LLC. All rights reserved.

Original publication

DOI

10.1080/07328319108046526

Type

Journal article

Journal

Nucleosides and Nucleotides

Publication Date

01/01/1991

Volume

10

Pages

555 - 561