Synthesis of base modified phosphorothioate oligodeoxynucleotides as inhibitors of HIV-1
Kemal O., Brown T., Burgess S., Bishop JD., Leigh-Brown AJ.
By the H-phosphonate approach on a solid support we have synthesised a 28-mer homopolymer of 2'-deoxycytidine (SdC28), a 28-mer phosphorothioate oligodeoxynucleotide (Srev) complementary to the HIV-1 regulatory gene and a number of its base modified derivatives. Anti HIV-1 activity of S-dC28 and Srev in chronically infected T-cells was studied. Melting temperatures of rev-comp rev and Srev-comp rev were also measured. © 1991, Taylor & Francis Group, LLC. All rights reserved.