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N(α)-t-Butoxycarbonyl-N(π)-benzyloxymethyl-L-histidine (1) and N(α)-t-butoxycarbonyl-N(π)-4-bromo-benzyloxymethyl-L-histidine (2) have been prepared and shown to be suitable derivatives for peptide synthesis with histidine; the synthetic intermediates had convenient physical properties, no side reactions were encountered, and the final deprotection proceeded smoothly under mild conditions.

Original publication




Journal article


Journal of the Chemical Society, Chemical Communications

Publication Date



648 - 649