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Inter-proton nuclear Overhauser enhancements (NOEs) have been used to assign the aromatic, anomeric and 2' resonances in the 1H nuclear magnetic resonance spectrum of the duplex formed between d(T-C-A-C-A-T) and d(A-T-G-T-G-A). The same techniques have been applied to assignments in the hybrid duplex formed by d(T-C-A-C-A-T) with r(A-U-G-U-G-A). Comparison of intra-residue with inter-residue NOEs yields structural information which suggests that the conformations of both duplexes are similar. The NOEs are consistent with inter-proton distances measured from models of B-form DNA. Circular dichroic results confirm these deductions.

Original publication




Journal article


Eur J Biochem

Publication Date





307 - 314


Chemical Phenomena, Chemistry, Circular Dichroism, Magnetic Resonance Spectroscopy, Nucleic Acid Hybridization, Oligodeoxyribonucleotides, Oligonucleotides, Protons, Solutions