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The Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reaction has been used to synthesize cyclic mini-DNA duplexes. The reaction is carried out on 5'-alkyne-3'-azide-labeled hairpin loop oligonucleotides and proceeds in high yield under mild conditions in as little as 5 min. The resultant duplexes have very high thermal stability and their CD spectra are characteristic of normal B-DNA. Copyright 2008 by John Wiley & Sons, Inc.


Journal article


Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]

Publication Date



Chapter 4