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Oligonucleotides have been ligated efficiently on solid-phase using CuAAC and SPAAC chemistry to produce up to 186-mer triazole linked DNA products. Multiple sequential ligation reactions can be carried out by using a masked azide approach. This work suggests a novel modular approach to the synthesis of large complex oligonucleotide analogues.

Original publication

DOI

10.1039/c3cc42451k

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

11/08/2013

Volume

49

Pages

6959 - 6961

Keywords

Click Chemistry, Molecular Structure, Oligonucleotides