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The transforming growth factor β (TGF-β) pathway acts as a double-edged sword in tumorigenesis. By constraining epithelial cell growth, TGF-β is a potent tumor suppressor. However, TGF-β also acts as a key player in the induction of epithelial-to-mesenchymal transition (EMT), thereby enhancing invasiveness and metastasis. Furthermore, TGF-β signaling has recently been correlated with resistance against both targeted and conventional anticancer agents. Here, we present data demonstrating a role for TGF-β in chemotherapy resistance in colorectal cancer (CRC). We discuss these results in the context of recent findings indicating TGF-β signaling as an emerging player in cancer drug resistance.

Original publication

DOI

10.4161/cc.26034

Type

Journal article

Journal

Cell Cycle

Publication Date

15/09/2013

Volume

12

Pages

2960 - 2968

Keywords

EMT, TGF-β, chemotherapy, drug resistance, Antineoplastic Agents, Apoptosis, Cell Line, Tumor, Colorectal Neoplasms, Drug Resistance, Neoplasm, Epithelial-Mesenchymal Transition, Humans, Mediator Complex, RNA Interference, RNA, Small Interfering, Signal Transduction, Smad2 Protein, Smad3 Protein, Transforming Growth Factor beta