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Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.

Original publication

DOI

10.1039/c3cc48151d

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

21/02/2014

Volume

50

Pages

1794 - 1796

Keywords

5-Methylcytosine, Cytosine, DNA, DNA Methylation, Models, Molecular, Nucleic Acid Conformation, Oxidation-Reduction, Protein Binding, Transcription Factors