Structural insights into how 5-hydroxymethylation influences transcription factor binding.
Lercher L., McDonough MA., El-Sagheer AH., Thalhammer A., Kriaucionis S., Brown T., Schofield CJ.
Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.