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Numerous in vitro studies have shown that human cell lines lacking functional ATM are extremely radiosensitive. In this issue, Moding et al. demonstrate using a murine model of sarcoma that deletion of the Atm gene has much less of a radiosensitizing effect on normal cardiac endothelia than on rapidly proliferating tumor endothelia. This work confounds our assumptions about the generality of the role of ATM in radiation sensitivity and the potential use of ATM inhibitors as radiosensitizers.

Original publication

DOI

10.1172/JCI77195

Type

Journal article

Journal

J Clin Invest

Publication Date

08/2014

Volume

124

Pages

3289 - 3291

Keywords

Animals, Ataxia Telangiectasia Mutated Proteins, Gene Deletion, Humans, Radiation Tolerance, Sarcoma, Experimental