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The spina bifida/anencephaly complex in man in some ways resembles the effects of T-locus mutants in the mouse. To test the hypothesis that these entities are genetically related, HL-A typing was performed in families with multiple cases of central nervous system abnormality. No evidence of linkage was found between HL-A type and the congenital malformation.


Journal article


Tissue Antigens

Publication Date





234 - 237


Animals, Child, Female, Genetic Linkage, HLA Antigens, Histocompatibility Antigens, Histocompatibility Testing, Humans, Male, Mice, Mutation, Spinal Dysraphism